文章基本信息

标题：Continuous immunotypes describe human immune variation and predict diverse responses
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作者：Kevin J. Kaczorowski ; Karthik Shekhar ; Dieudonné Nkulikiyimfura 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：30
页码：E6097-E6106
DOI：10.1073/pnas.1705065114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The immune system consists of many specialized cell populations that communicate with each other to achieve systemic immune responses. Our analyses of various measured immune cell population frequencies in healthy humans and their responses to diverse stimuli show that human immune variation is continuous in nature, rather than characterized by discrete groups of similar individuals. We show that the same three key combinations of immune cell population frequencies can define an individual’s immunotype and predict a diverse set of functional responses to cytokine stimulation. We find that, even though interindividual variations in specific cell population frequencies can be large, unrelated individuals of younger age have more homogeneous immunotypes than older individuals. Across age groups, cytomegalovirus seropositive individuals displayed immunotypes characteristic of older individuals. The conceptual framework for defining immunotypes suggested by our results could guide the development of better therapies that appropriately modulate collective immunotypes, rather than individual immune components.
关键词：human immune variation ; immune cell composition ; systems immunology ; aging