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标题：EFFECTS OF SYNBIOTIC FOOD CONSUMPTION ON SERUM MINERALS, LIVER ENZYMES, AND BLOOD PRESSURE IN PATIENTS WITH TYPE 2 DIABETES: A DOUBLE?BLIND RANDOMIZED CROSS?OVER CONTROLLED CLINICAL TRIAL
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作者：ASEMI ZATOLLAH ; AARABI MOHAMMAD HOSSEIN ; HAJIJAFARI MOHAMMAD 等
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2017
卷号：8
期号：-
页码：0-0
语种：English
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: This research was to examine the effects of synbiotic intake on minerals, liver enzymes, and blood pressure in patients with type 2 diabetes (T2D).
Methods: This randomized, cross?over clinical trial was performed among 62 diabetic patients. Persons were randomly assigned to intake either a synbiotic (n=62) or a control food (n=62) for 6 weeks. A 3?week washout period was applied following which persons were crossed over to the alternate intervention arm for an additional 6 weeks. The synbiotic was consisted of Lactobacillus sporogenes (1 × 10⁷ CFU), 0.04 g inulin (HPX) as prebiotic. Persons were asked to consume the synbiotic and control foods 27 g a day. Blood pressure was measured, and blood samples were taken at baseline and after 6?week intervention to assess calcium, magnesium, iron, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and total bilirubin.
Results: The consumption of a synbiotic food, compared to the control food, resulted in a significant rise of calcium (0.66 vs. ?0.14 mg/dL, P=0.03) and iron (5.06 vs. ?9.98 mg/dL, P=0.03). The decrease of total bilirubin (0.08 vs. ?0.04 mg/dL; P=0.009) was also seen in the synbiotic group compared with the control group. Conclusions: Overall, synbiotic in T2D patients had beneficial effects on calcium, iron, and total bilirubin concentrations.
关键词：BLOOD PRESSURE; LIVER ENZYMES; SERUM MINERALS; SYNBIOTIC; TYPE 2 DIABETES