文章基本信息

标题：The hazards of hazard identification in environmental epidemiology
本地全文：下载
作者：Rodolfo Saracci
期刊名称：Environmental Health - a Global Access Science Source
印刷版ISSN：1476-069X
电子版ISSN：1476-069X
出版年度：2017
卷号：16
期号：1
页码：85
DOI：10.1186/s12940-017-0296-3
语种：English
出版社：BioMed Central
摘要：Hazard identification is a major scientific challenge, notably for environmental epidemiology, and is often surrounded, as the recent case of glyphosate shows, by debate arising in the first place by the inherently problematic nature of many components of the identification process. Particularly relevant in this respect are components less amenable to logical or mathematical formalization and essentially dependent on scientists’ judgment. Four such potentially hazardous components that are capable of distorting the correct process of hazard identification are reviewed and discussed from an epidemiologist perspective: (1) lexical mix-up of hazard and risk (2) scientific questions as distinct from testable hypotheses, and implications for the hierarchy of strength of evidence obtainable from different types of study designs (3) assumptions in prior beliefs and model choices and (4) conflicts of interest. Four suggestions are put forward to strengthen a process that remains in several aspects judgmental, but not arbitrary, in nature.
关键词：Bayes’ theorem ; Conflict of interest ; Hazard identification ; IARC Monographs ; Linearity ; Model assumptions ; Risk assessment ; Threshold