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  • 标题:A red yeast rice-olive extract supplement reduces biomarkers of oxidative stress, OxLDL and Lp-PLA 2 , in subjects with metabolic syndrome: a randomised, double-blind, placebo-controlled trial
  • 本地全文:下载
  • 作者:Nina Hermans ; Anastasia Van der Auwera ; Annelies Breynaert
  • 期刊名称:Trials
  • 印刷版ISSN:1745-6215
  • 电子版ISSN:1745-6215
  • 出版年度:2017
  • 卷号:18
  • 期号:1
  • 页码:302
  • DOI:10.1186/s13063-017-2058-5
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:Background Metabolic syndrome (MetS) refers to clustered cardiovascular risk factors (abdominal obesity, pre-diabetes, high blood pressure, dyslipidaemia). Therapies targeting oxidative stress may delay progression to atherosclerosis and diabetes. We investigated the anti-oxidative effect of a supplement combining red yeast rice and olive extract in patients with MetS. Methods A double-blind, placebo-controlled, randomised trial was conducted with 50 patients with MetS as defined by National Cholesterol Education Program Adult Treatment Panel III criteria. Forty-nine subjects randomly assigned to red yeast rice-olive extract (RYR-olive extract; 10.82 mg of monacolins and 9.32 mg of hydroxytyrosol per Cholesfytolplus capsule) or placebo completed the 8-week trial. Whereas effects on cardiovascular risk parameters of MetS have been reported recently, the observed significant 20% increase in oxidised low-density lipoprotein (OxLDL) prompted us to investigate other oxidative stress-related parameters: malondialdehyde (MDA), lipoprotein-associated phospholipase A2 (Lp-PLA2) and 8-hydroxy-2′-deoxyguanosine (8-OHdG). Statistical calculations included univariate quantitative analysis, multivariate linear regression and correlation analysis. Results The updated results indicate that an RYR-olive extract supplement significantly reduced Lp-PLA2 by 7% ( p p > 0.05). Reductions in OxLDL (20%) and Lp-PLA2 (7%) were associated with each other ( r = 0.740, p Conclusions RYR-olive extract significantly reduced Lp-PLA2 in correlation with the marked reduction in plasma OxLDL, which may lead to a reduced risk for cardiovascular disease in patients with MetS. Trial registration ClinicalTrials.gov identifier: NCT02065180 . Registered on 13 February 2014.
  • 关键词:Metabolic syndrome ; Red yeast rice ; Olive ; Oxidative stress
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