文章基本信息

标题：Chromaffin cell transplantation for neuropathic pain after spinal cord injury: a report of two cases
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作者：Lin Chen ; Haitao Xi ; Juan Xiao 等
期刊名称：Journal of Neurorestoratology
电子版ISSN：2324-2426
出版年度：2017
卷号：5
页码：47-50
DOI：10.2147/JN.S120173
语种：English
出版社：Dove Medical Press Ltd
摘要：Neuropathic pain (NP), a common secondary complication following spinal cord injury (SCI), presenting at or below the level of injury is largely refractory to current pharmacological, physical, and surgical treatments. Previous studies have demonstrated the promising value of cell therapy including adrenal chromaffin cells that have the capacity to act as mini-pumps that release amines and peptides for alleviating chronic pain. The paper presents the cases of two gentlemen suffering from severe central NP after thoracic SCI. Six months after chromaffin cell intrathecal injection, their pain relieved significantly. The results demonstrated the preliminary therapeutic efficacy of chromaffin cell transplants in people with NP, and support further research of this treatment strategy for the management of intractable chronic pain due to SCI.
关键词：chromaffin cell; cell transplantation; neuropathic pain; spinal cord injury