文章基本信息

标题：Omega-3 carboxylic acids monotherapy and combination with statins in the management of dyslipidemia
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作者：Lane B Benes ; Nikhil S Bassi ; Michael H Davidson 等
期刊名称：Vascular Health and Risk Management
印刷版ISSN：1176-6344
电子版ISSN：1178-2048
出版年度：2016
卷号：12
页码：481-490
DOI：10.2147/VHRM.S58149
语种：English
出版社：Dove Medical Press Ltd
摘要：The 2013 American College of Cardiology/American Heart Association guidelines on cholesterol management placed greater emphasis on statin therapy given the well-established benefits in primary and secondary prevention of cardiovascular disease. Residual risk may remain after statin initiation, in part because of triglyceride-rich lipoprotein cholesterol. Several large trials have failed to show benefit with non-statin cholesterol-lowering medications in the reduction of cardiovascular events. Yet, subgroup analyses showed a benefit in those with hypertriglyceridemia and lower high-density lipoprotein cholesterol level, a high-risk pattern of dyslipidemia. This review discusses the benefits of omega-3 carboxylic acids, a recently approved formulation of omega-3 fatty acid with enhanced bioavailability, in the treatment of dyslipidemia both as monotherapy and combination therapy with a statin.
关键词：omega-3 carboxylic acids; non-HDL-C; hypertriglyceridemia; residual risk; statin