文章基本信息

标题：Peripherally acting μ-opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy
本地全文：下载
作者：Joseph V Pergolizzi Jr ; Robert B Raffa ; Marco Pappagallo 等
期刊名称：Patient Preference and Adherence
印刷版ISSN：1177-889X
电子版ISSN：1177-889X
出版年度：2017
卷号：11
页码：107-119
DOI：https://doi.org/10.2147/PPA.S78042
出版社：Dove Medical Press Ltd
摘要：Opioid-induced constipation (OIC), a prevalent and distressing side effect of opioid therapy, does not reliably respond to treatment with conventional laxatives. OIC can be a treatment-limiting adverse event. Recent advances in medications with peripherally acting μ-opioid receptor antagonists, such as methylnaltrexone, naloxegol, and alvimopan, hold promise for treating OIC and thus extending the benefits of opioid analgesia to more chronic pain patients. Peripherally acting μ-opioid receptor antagonists have been clinically tested to improve bowel symptoms without compromise to pain relief, although there are associated side effects, including abdominal pain. Other treatment options include fixed-dose combination products of oxycodone analgesic together with naloxone.
关键词：opioid-induced constipation; opioid bowel disorder; PAMORA; peripherally acting mu-opioid receptor antagonist; noncancer pain patients; opioid-associated side effects