文章基本信息

标题：Point-of-Care-Testing in Acute Stroke Management: An Unmet Need Ripe for Technological Harvest
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作者：Dorin Harpaz
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2017
卷号：7
期号：3
页码：30
DOI：10.3390/bios7030030
语种：English
出版社：MDPI Publishing
摘要：Stroke, the second highest leading cause of death, is caused by an abrupt interruption of blood to the brain. Supply of blood needs to be promptly restored to salvage brain tissues from irreversible neuronal death. Existing assessment of stroke patients is based largely on detailed clinical evaluation that is complemented by neuroimaging methods. However, emerging data point to the potential use of blood-derived biomarkers in aiding clinical decision-making especially in the diagnosis of ischemic stroke, triaging patients for acute reperfusion therapies, and in informing stroke mechanisms and prognosis. The demand for newer techniques to deliver individualized information on-site for incorporation into a time-sensitive work-flow has become greater. In this review, we examine the roles of a portable and easy to use point-of-care-test (POCT) in shortening the time-to-treatment, classifying stroke subtypes and improving patient’s outcome. We first examine the conventional stroke management workflow, then highlight situations where a bedside biomarker assessment might aid clinical decision-making. A novel stroke POCT approach is presented, which combines the use of quantitative and multiplex POCT platforms for the detection of specific stroke biomarkers, as well as data-mining tools to drive analytical processes. Further work is needed in the development of POCTs to fulfill an unmet need in acute stroke management.
关键词：Stroke; Diagnostics; Point-of-Care-Test; Biomarkers; Time-Dependent Treatment; Multiplex and Quantitative Detection; Data-Mining Stroke ; Diagnostics ; Point-of-Care-Test ; Biomarkers ; Time-Dependent Treatment ; Multiplex and Quantitative Detection ; Data-Mining