首页    期刊浏览 2024年12月11日 星期三
登录注册

文章基本信息

  • 标题:Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma
  • 本地全文:下载
  • 作者:Bui, Timothy T. ; Lagman, Carlito ; Chung, Lawrance K.
  • 期刊名称:Brain Tumor Research and Treatment
  • 印刷版ISSN:2288-2405
  • 出版年度:2017
  • 卷号:5
  • 期号:1
  • 页码:10-15
  • DOI:10.14791/btrt.2017.5.1.10
  • 语种:English
  • 出版社:The Korean Brain Tumor Society and The Korean Society for Neuro-Oncology
  • 摘要:

    Central neurocytoma (CN) typically presents as an intraventricular mass causing obstructive hydrocephalus. The first line of treatment is surgical resection with adjuvant conventional radiotherapy. Stereotactic radiosurgery (SRS) was proposed as an alternative therapy for CN because of its lower risk profile. The objective of this systematic analysis is to assess the efficacy of SRS for CN. A systematic analysis for CN treated with SRS was conducted in PubMed. Baseline patient characteristics and outcomes data were extracted. Heterogeneity and publication bias were also assessed. Univariate and multivariate linear regressions were used to test for correlations to the primary outcome: local control (LC). The estimated cumulative rate of LC was 92.2% (95% confidence interval: 86.5-95.7%, p <0.001). Mean follow-up time was 62.4 months (range 3-149 months). Heterogeneity and publication bias were insignificant. The univariate linear regression models for both mean tumor volume and mean dose were significantly correlated with improved LC ( p <0.001). Our data suggests that SRS may be an effective and safe therapy for CN. However, the rarity of CN still limits the efficacy of a quantitative analysis. Future multi-institutional, randomized trials of CN patients should be considered to further elucidate this therapy.

  • 关键词:Brain tumors; Neurocytoma, central; Gamma knife radiosurgery; Linear accelerators; Stereotactic radiosurgery
国家哲学社会科学文献中心版权所有