文章基本信息

标题：Frontotemporal Dementia with Motor Neuron Disease in a Patient with Antiphospholipid Syndrome: A Case Report
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作者：Jeong, Yoon-Cheol ; Park, Jin-Seok ; Kim, Seung-Hyun 等
期刊名称：Dementia and Neurocognitive Disorders
印刷版ISSN：1738-1495
出版年度：2016
卷号：15
期号：4
页码：165-169
DOI：10.12779/dnd.2016.15.4.165
语种：English
出版社：KoreaMed Synapse
摘要：Background
Frontotemporal dementia (FTD) with motor neuron disease (MND) is a syndrome of progressive changes in behavior, language, muscle weakness and atrophy due to loss of function of neurons in the frontal and temporal lobes and in motor neurons. Etiology and pathogenesis of FTD with MND are still uncertain.
Case Report
A 71-year-old man presented with a 2-year history of progressive muscle weakness and cognitive deficits. We diagnosed this patient as FTD with MND by neurological examination, electromyography, brain imaging and neuro-psychological evaluation. We also confirmed antiphospholipid syndrome (APS) in this patient as a way to rule out secondary causes of MND.
Conclusions
This was a very rare case of FTD with MND in APS. We should focus study on the possible role of autoimmune pathogenesis in FTD with MND.
关键词：frontotemporal dementia; Motor Neuron Disease; Antiphospholipid syndrome