文章基本信息

标题：Phenotype Development of Long Tailed Monkey ( Macaca fascicularis ) Fed Obese Diet
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作者：Deyv Pijoh ; Sri Supraptini Mansjoer ; Dondin Sajuthi 等
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2017
卷号：16
期号：5
页码：364-371
DOI：10.3923/pjn.2017.364.371
出版社：Asian Network for Scientific Information
摘要：Objective: This study was conducted to develop an animal model of obesity by monitoring the phenotypes of long-tailed monkeys ( Macaca fascicularis ) fed a high energy diet. Methodology: Fifteen adult male Long-Tailed Monkeys (LTM) weighing between 4 and 5 kg were divided into three groups of five that received one of three diets: Diet A: A commercial monkey chow diet, Diet B: Monkey chow supplemented with egg yolk and Diet C: In which wheat was the main ingredient and beef tallow was added. Body measurements, including body weight were collected monthly. Results: The LTM fed Diet B (Egg yolk-supplemented) consumed more food compared to those fed Diet A and C. Animals in the Diet B group had significantly (p<0.01) larger waist circumference, hip circumference, chest circumference and skin fold thickness compared to the other two groups. There was a close relationship between body weight and waist circumference (r = 0.863), chest circumference (r = 0.889) and hip circumference (r = 0.890). Based on the main component analysis, LTM fed Diet B had higher rates of obesity compared to LTM fed Diet A or C. Conclusion: Body characteristics of LTM fed different diets can be used to determine the presence of obesity. The LTM can serve as a useful animal model of obesity and findings from this model can be applied to studies of obesity in humans.