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标题：Effect of Average Annual Mean Serum Ferritin Levels on QTc Interval and QTc Dispersion in Beta-Thalassemia Major
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作者：Yazdan Ghandi ; Mehrzad Sharifi ; Aziz Eghbali 等
期刊名称：International Journal of Pediatrics
印刷版ISSN：2345-5047
电子版ISSN：2345-5055
出版年度：2017
卷号：5
期号：8
页码：5431-5440
DOI：10.22038/ijp.2017.24296.2051
语种：English
出版社：Mashhad University of Medical Sciences
其他摘要：Background There is evidence indicating impaired cardiomyocytic contractility, delayed electrical conduction and increased electrophysiological heterogeneities due to iron toxicity in beta-thalassemia major patients. In the present study, we compared the electrocardiographic and echocardiographic features of beta-thalassemia major patients with a healthy control group. Materials and Methods The average annual serum ferritin levels of fifty beta-thalassemia major patients were assessed. For each patient, corrected QT (QTc) intervals and QTc dispersions (QTcd) were calculated and V1S and V5R were measured. All subjects underwent two-dimensional M-mode echocardiography and Doppler study and were compared with 50 healthy subjects as a control group. Results QTc interval and dispersion were significantly higher in beta-thalassemia major patients (P= 0.001). The mean V5R (20.04 ± 4.34 vs. 17.14 ± 2.55 mm) and V1S (10.24 ± 2.62 vs. 7.83 ± 0.38 mm) showed considerably higher mean values in patients in comparison with control group.Peak mitral inflow velocity at early diastole and early to late ratio in the case- group was markedly higher(P
其他关键词：Arrhythmia; Beta-thalassemia major; Ferritin