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标题：Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Benefit Cognition in Frail Elderly Adults: A Randomized Controlled Trial
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作者：Sakiko ABE ; Osamu EZAKI ; Motohisa SUZUKI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2017
卷号：63
期号：2
页码：133-140
DOI：10.3177/jnsv.63.133
出版社：Center for Academic Publications Japan
摘要：The combined supplementation of medium-chain triglycerides (MCTs), L -leucine-rich amino acids, and cholecalciferol (vitamin D₃) increase muscle strength and function in frail elderly individuals. However, their effects on cognition are unknown. We enrolled 38 elderly nursing home residents (mean age±SD, 86.6±4.8 y) in a 3-mo randomized, controlled, parallel group trial. The participants were randomly allocated to 3 groups: the first group received a L -leucine (1.2 g)- and cholecalciferol (20 μg)-enriched supplement with 6 g of MCT (LD+MCT); the second group received the same supplement with 6 g of long-chain triglycerides (LD+LCT); and the third group did not receive any supplements (control). Cognition was assessed at baseline and after the 3-mo intervention. The difference in changes among the groups was assessed with ANCOVA, adjusting for age and the baseline value as covariates. After 3 mo, the Mini-Mental State Examination (MMSE) score in the LD+MCT group increased by 10.6% (from 16.6 to 18.4 points, p p p p L -leucine-rich amino acids, and cholecalciferol may improve cognitive function in frail elderly individuals.
关键词：MCT;vitamin D;leucine;cognition;Alzheimer’s disease