文章基本信息

标题：Immunochemical engineering of cell surfaces to generate virus resistance
本地全文：下载
作者：Jia Xie ; Devin Sok ; Nicholas C. Wu 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：18
页码：4655-4660
DOI：10.1073/pnas.1702764114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Modern immunochemical engineering allows the creation of cells that either secrete antibodies or incorporate them into various cellular compartments, including the plasma membrane. Because the receptors for most viruses are known, if one can achieve the proper stoichiometry and geometry, plasma membrane-associated antibodies to these receptors should block viral infection. In this report, we test this concept for two different viruses, human rhinovirus and HIV. Plasma membrane-tethered antibodies efficiently rendered cells permanently nonpermissive for infection by both these viruses. Membrane-bound antibodies were much more efficient than free antibody in preventing infection, likely because of the effective molarity of membrane bound antibodies. Such resistant cells may restore immune-competence to otherwise compromised HIV patients.
关键词：HIV ; cell surfaces ; prevention