文章基本信息

标题：A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening
本地全文：下载
作者：Gita V. Soraya
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2017
卷号：7
期号：2
页码：19
DOI：10.3390/bios7020019
语种：English
出版社：MDPI Publishing
摘要：The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings. The label-free prototype has a lower limit of detection (LOD) of 10 µg hemoglobin per gram (Hb/g) of feces, comparable to that of conventional laboratory based quantitative FIT diagnostic systems.
关键词：biosensors; immunosensor; interdigitated electrodes; colorectal cancer; screening; impedance; point of care; label-free; diagnostics biosensors ; immunosensor ; interdigitated electrodes ; colorectal cancer ; screening ; impedance ; point of care ; label-free ; diagnostics