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标题：Acute toxicity of grayanotoxin III on total protein and electrophoresis fractions in rat serum
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作者：Koichi FUKUMOTO ; Tadahiro TETSUMI ; Yoko NISHIKAWA 等
期刊名称：生活衛生
印刷版ISSN：0582-4176
电子版ISSN：1883-6631
出版年度：1993
卷号：37
期号：2
页码：73-77
DOI：10.11468/seikatsueisei1957.37.73
出版社：Osaka Urban Living and Health Association
摘要：Acute toxicity of grayanotoxin (GTX) III on total protein and electrophoresis fractions in rat serum was studied. To evaluate the effect of GTX III on rats, 0.8 or 2.8mg/kg was injected and biochemicals in rat sera were examined. From 1 hour after the injection, hyperproteinemia appeared with increase of total protein and albumin in serum, possibly due to the dehydration. Electrophoresis of the proteins showed an increase of α₁-globulin and a decrease of γ-globulin. The protein abnormalities revealed by the electrophoretic patterns were of a typical acute stress type caused by abrupt dysfunction of the homeostatic eqilibrium. GTX III also caused an increase in the serum activities of guanase and alanine aminotransferase, which are enzymes mainly contained in rat liver. These results showed the acute toxicity of GTX III to include hypreproteinemia by dehydration, the changes of globulins, and liberation of liver enzymes such as guanase and alanine aminotransferase.