文章基本信息

标题：たん白質栄養におけるビタミンB6の役割
本地全文：下载
作者：岡田美津子
期刊名称：日本栄養・食糧学会誌
印刷版ISSN：0287-3516
电子版ISSN：1883-2849
出版年度：1975
卷号：28
期号：7
页码：353-361
DOI：10.4327/jsnfs1949.28.353
出版社：Japanese Society of Nutrition and Food Science
摘要：This review summarizes our work on some aspects of amino acid and protein metabolism in B₆-deficient rats. 1. Functions of B₆ enzymes of mitochondrial origin, especially aspartate and ornithine transaminases, were studied. The former enzyme was shown to produce aspartate from glutamate efficiently by coupling with TCA cycle. The latter enzyme catalyzed an efficient conversion of α-ketoglutarate, a member of TCA cycle, to glutamate. 2. In rat liver some B₆ enzymes predominantly exist as holoenzymes while others exist as apoenzymes to a considerable degree. The changes of absolute amounts as well as apo/holo ratios of representative B₆ enzymes in B₆ deficiency were studied. 3. Severity of B₆ deficiency in the rats fed 70% or 10% casein diet was compared. Severe deficiency was observed in the rats fed 70% casein diet as evidenced by a retardation of growth, and decreases in pyridoxal content and enzyme activities in the livers. 4. Metabolic disorders were studied in the rat fed the 70% casein B₆-deficient diet. a. In B₆ deficient rats, the changes of hepatic enzyme activities did not necessarily reflect the degrees of impairment of amino acid metabolism. In the deficient animals, metabolism of glycine, serine, threonine and some members of urea cycle was markedly impaired. b. Fatty liver was induced in the deficient rats as a result of accumulation of triglyceride and cholesterol ester.