文章基本信息

标题：活性酸素による8-ヒドロキシグアニンの生成と生体との関わり : 変異誘発・発がん・修復
本地全文：下载
作者：紙谷浩之 ; 葛西宏
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1995
卷号：41
期号：5
页码：307-319
DOI：10.1248/jhs1956.41.307
出版社：The Pharmaceutical Society of Japan
摘要：Reactive oxygen species (ROS) are produced by the normal oxygen metabolism in cells as a consequence of respiration in an oxygen atmosphere and by some kinds of environmental mutagens. ROS attack and modify cellular macromolecules including DNA. 8-Hydroxyguanine (8-OH-Gua) is one of the DNA lesions which are produced by ROS. 8-OH-Gua mainly induces G→T mutations in vitro, in E. coli and mammalian cells. Repair enzymes for 8-OH-Gua are present in cells and prevent the mutations induced by the DNA lesion. Formation of oxidative DNA lesions which are produced by ROS appears to be involved in many biological processes including carcinogenesis and ageing. Therefore, 8-OH-Gua may be a good marker of cellular production of ROS to estimate mutagenicities and carcinogenicities of chemical compounds.
关键词：8-hydroxyguanine;oxygen radical;mutagenesis;carcinogenesis;repair