文章基本信息

标题：杜仲, 黄耆の培養細胞に対する染色体異常誘発能と杜仲のAmes変異原性画分の性質
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作者：只木晋一 ; 山田さゆり ; 宮澤法政等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1995
卷号：41
期号：6
页码：463-469
DOI：10.1248/jhs1956.41.463
出版社：The Pharmaceutical Society of Japan
摘要：In order to further investigate the genotoxic effects of Sophorae Flos, Astragali Radix and Eucommiae Cortex which are reported to induce mutagenicity in Ames test, a chromosome aberration study of the water extracts of these crude drugs was carried out using cultured Chinese hamster lung cells. Sophorae Flos did not induce chromosomal aberrations in either direct method or S9 Mix method. In the S9 Mix method, Astragali Radix at a dose of 1.25 mg/ml modestly increased the incidence of aberrant cells (16%). Eucommiae Cortex was strongly clastogenic to the cells and dramatically elevated the incidence of aberrant cells (98%) at a concentration of 4.55 mg/ml in the direct method. These results suggest that Astragali Radix and Eucommiae Cortex may be genotoxic to mammalian cells
关键词：clastogenicity;Sophorae Flos;Astragali Radix;Eucommiae Cortex;Ames test;mutagenicity