文章基本信息

标题：The Effect of Bio-antimutagens on Chlorambucil and Methotrexate Using the Wing Spot Test in Drosophila melanogaster
本地全文：下载
作者：TAKAHIKO SATO ; HAJIME NISHINO ; HISAMITSU NAGASE 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1995
卷号：41
期号：6
页码：452-457
DOI：10.1248/jhs1956.41.452
出版社：The Pharmaceutical Society of Japan
摘要：When certain mutagenic anti-cancer medicines are used for cancer therapy, secondary production of cancer by the medicines themselves is feared. Certain bio-antimutagenic substances may decrease secondary cancer induction without interfering with the effectiveness of the anti-cancer therapies. The bio-antimutagenic effects of cobaltous chloride, gallic acid, taurine and isethionate on the anti-cancer medicines chlorambucil and methotrexate were investigated using the Drosophila melanogaster wing spot test. Cobaltous chloride reduced the mutagenicity of methotrexate, but not chlorambucil. Gallic acid reduced the mutagenicity of both medicines. Taurine and isethionate also reduced the mutagenicity of methotrexate.
关键词：bio-antimutagenicity;wing spot test;anti-cancer medicine;Drosophila melanogaster