文章基本信息

标题：ラットに気管内投与した重金属の影響(第2報)塩化カドミウムの投与後の肺の元素濃度の変化
本地全文：下载
作者：小林悦子 ; 須長宏行 ; 鈴木和夫等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1987
卷号：33
期号：5
页码：360-364
DOI：10.1248/jhs1956.33.360
出版社：The Pharmaceutical Society of Japan
摘要：Cadmium chloride dissolved in physiological saline (0.4 ml) was instilled intratracheally into male Wistar rats (10 weeks old ; body weight, approximately 270 g) at eight doses (40-0.313 μg Cd/rat). Concentrations of elements (calcium, copper, iron, magnesium, phosphorus, sulfur and zinc) in the lung were determined along with cadmium by inductively coupled argon plasma-atomic emission spectrometry (ICP) and/or flameless Zeeman atomic absorption spectrophotometry. The body weight decreased significantly, while the lung weight increased significantly at doses higher than 5.0 μg Cd/rat. Changes in lung weight and element concentrations suggested that lung edema was induced at a dose of as low as 2.5 μg Cd/rat. Distributions of copper and zinc in the supernatants of the lungs were determined on a gel permeation column by high performance liquid chromatography-ICP, indicating that superoxide dismutase in the lung decreased with a cadmium instillation at doses higher than 2.5 μg Cd/rat.
关键词：cadmium;intratracheal instillation;lung;lung edema;copper;superoxide dismutase