文章基本信息

标题：ラットに気管内投与した重金属の影響(第1報)塩化カドミウムの投与量に依存した肺への取り込みと肝への移行
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作者：小林悦子 ; 鈴木和夫
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1987
卷号：33
期号：5
页码：356-359
DOI：10.1248/jhs1956.33.356
出版社：The Pharmaceutical Society of Japan
摘要：Uptake and absorption of cadmium (Cd) through the airway were examined by determining the dose-dependent accumulation in the lung and its transfer to other organs after a single intratracheal instillation of cadmium chloride into rats. Male rats of the Wistar strain (10 weeks old ; body weight, 270±10 g (mean±S.D.)) were instilled with Cd dissolved in 0.4 ml saline at eight doses (0.313-40 μg Cd/rat) and killed two days later. Concentrations (μg/g tissue) and contents (μg/tissue) of Cd in the lung, liver, kidney and spleen were determined by flameless Zeeman atomic absorption spectrophotometry and/or inductively coupled argon plasma-atomic emission spectrometry (ICP). More than 90% of Cd were accumulated in the lung when the dose was lower than 2.5 μg Cd/rat, while the percentage of Cd accumulated in the lung decreased steeply at higher doses than 5 μg Cd/rat and the metal was transferred predominantly to the liver.
关键词：cadmium;intratracheal-instillation;lung;cadmium-accumulation