文章基本信息

标题：m-ジクロロベンゼン及びその含硫代謝物のマウス肝薬物代謝酵素系に及ぼす影響
本地全文：下载
作者：相本太刀夫 ; 福島利男 ; 今井公江等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1988
卷号：34
期号：1
页码：52-58
DOI：10.1248/jhs1956.34.52
出版社：The Pharmaceutical Society of Japan
摘要：Sulfur-containing metabolites, 2, 4-dichlorophenyl methyl sulfoxide, 2, 4-dichlorophenyl methyl sulfone (2, 4-DCPSO₂CH₃), 3, 5-dichlorophenyl methyl sulfoxide and 3, 5-dichlorophenyl methyl sulfone (3, 5-DCPSO₂CH₃) were all found in the urine of both male and female mice given orally a 200 mg/kg dose of m-dichlorobenzene (m-DCB). m-DCB (200 mg/kg) given to mice of both sexes by either oral or intraperitoneal (i.p.) route increased the activities of aminopyrine N-demethylase (AD) and aniline hydroxylase, and the content of cytochrome P-450 in the liver microsomes. 3, 5-DCPSO₂CH₃ (100μmol/kg, i.p.) induced markedly the enzyme system in mice of both sexes. On the other hand, 2, 4-DCPSO₂CH₃ (100 μmol/kg, i.p.) decreased significantly the AD activity in the males and the cytochrome b₅ content in the females. An i.p. administration of m-DCB, 2, 4-DCPSO₂CH₃ or 3, 5-DCPSO₂CH₃ also caused a marked increase in epoxide hydrolase activity in the livers of the male and female mice, except that 2, 4-DCPSO₂CH₃ had no effect on the enzyme activity in the females. Thus, the differences in the effects of 2, 4- and 3, 5-DCPSO₂CH₃ on the enzyme system were demonstrated and the sex differences in the effects of the sulfones were also found in mice.
关键词：m-dichlorobenzene;sulfur-containing metabolite;mouse liver;microsome;drugmetabolizing enzyme;9000×g supernatant;epoxide hydrolase