文章基本信息

标题：大麻成分, テトラヒドロカンナビノール, カンナビジオール及び活性代謝物とシンナー及びその含有成分との相互作用
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作者：山本郁男 ; 西上潤 ; 渡辺和人等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1988
卷号：34
期号：6
页码：542-545
DOI：10.1248/jhs1956.34.542
出版社：The Pharmaceutical Society of Japan
摘要：The interaction of cannabinoids, tetrahydrocannabinol (THC), cannabidiol (CBD) and some active metabolites with thinner and its components was studied in mice and the following results were obtained. 1) Δ⁹-THC but not CBD (5 mg/kg, i.v.) significantly prolonged thinner-induced anesthesia by 1.8 fold. The latent period to induce the anesthesia was significantly shortened by Δ⁹-THC. 2) 11-Hydroxy-Δ⁸-THC and 11-oxo-Δ⁸-THC (5 mg/kg, i.v.), which are active metabolites of Δ⁸-THC, significantly prolonged thinner-induced anesthesia by 2.0 and 3.2 fold, respectively. 11-Oxo-Δ⁸-THC significantly shortened latent period to induce the anesthesia. 3) Among cannabinoids examined, only 11-hydroxy-Δ⁸-THC significantly prolonged toluene-induced anesthesia by 2.4 fold. Thinner contains about 60% of toluene and a small amount of ethyl acetate, ethylether and ethylalcohol. 4) Δ⁸-THC and its active metabolites, 11-hydroxy-Δ⁸-THC and 11-oxo-Δ⁸-THC significantly prolonged ethyl acetate-induced anesthesia by 4.4, 4.9 and 5.1 fold, respectively. Moreover, Δ⁸-THC, 11-hydroxy-Δ⁸-THC and 11-oxo-Δ⁸-THC significantly shortened latent period to induce anesthesia.
关键词：Δ9-tetrahydrocannabinol;Δ8-tetrahydrocannabinol;cannabidiol;active metabolite;thinner;toluene;ethyl acetate;anesthesia in mice