文章基本信息

标题：市販黄色5号の不純物のショウジョウバエ毒性試験
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作者：河井一明 ; 古川秀之 ; 椛澤洋三等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1993
卷号：39
期号：4
页码：332-335
DOI：10.1248/jhs1956.39.4_332
出版社：The Pharmaceutical Society of Japan
摘要：Commercial Food Yellow No.5 showed genotoxic activity in Drosophila wing spot test. Seventy-two hours larvae of Drosophila were treated chronically (during the whole third larval instar) with commercial Food Yellow No.5. The frequencies of single spots increased 4-fold that of control. Commercial Food Yellow No.5 involved some impurities. Impurity fraction A, which contained more polar compounds than Food Yellow No.5, showed DNA damage in Drosophila DNA-repair test. These results suggested that the impurities would be contributed to the genotoxicity of commercial Food Yellow No.5.
关键词：Drosophila melanogaster;wing spot test;DNA-repair test;Food Yellow No.5;genotoxicity;somatic mutation