文章基本信息

标题：Metabolism, Distribution and Excretion of 2, 2, 3, 3, 3-Pentafluoropropanol in Rats
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作者：KENICHIRO MINEGISHI ; ATSUSHI TAKAHASHI
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1996
卷号：42
期号：1
页码：17-27
DOI：10.1248/jhs1956.42.17
出版社：The Pharmaceutical Society of Japan
摘要：The elimination and metabolism of 2, 2, 2, 3, 3-pentafluoropropanol (5-FP) were investigated in male and female rats for 7 d after a single oral administration at doses of 4, 40, and 400 mg/kg. 5-FP glucuronide and 2, 2, 3, 3, 3-pentafluoropropionic acid (5-FPA) as major metabolites were determined by head-space analysis using GC-MS in the selected ion monitoring-mode. 5-FP glucuronide and 5-FPA were found in urine and feces of both male and female rats. The cumulative excretion of 5-FP in the urine was 28.6-59.3% of the dose and only 0.46-1.28% in the feces in both sexes. A sex-related difference in urinary excretion of 5-FPA was observed in the two dose levels (4 and 40 mg/kg). The recoveries of 5-FPA in the urine of rats administered 5-FP were 10.7-11.9% in male and 33.0-38.2% in female by 7 d post treatment. The sex-related difference of biological half-lives (t_1/2) were also observed in some tissues such as liver, kidney and blood.
关键词：2, 2, 3, 3, 3-pentafluoropropanol;metabolism (rat);tissue distribution;excretion;2, 2, 3, 3, 3-pentafluoropropionic acid