文章基本信息

标题：尿中のニコチン, コチニン量及び尿の変異原性に及ぼす喫煙の影響
本地全文：下载
作者：小谷野道子 ; 尾池吉保 ; 後藤純雄等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1996
卷号：42
期号：3
页码：263-267
DOI：10.1248/jhs1956.42.263
出版社：The Pharmaceutical Society of Japan
摘要：A versatile analytical method using liquid-liquid extraction and GC/MS for nicotine and cotinine in the urine was developed. Concentrations of nicotine and cotinine in the urine from 5 non-smokers and 6 smokers were analyzed by this method. The levels of nicotine and cotinine in the urine of smokers were 17-2200 ng/ml and 120-3200 ng/ml, respectively. On the contrary, their levels in the urine of non-smokers were below the detection limit except persons accepting passive smoking. The variations of the concentrations of nicotine and cotinine and that of mutagenic activity after smoking were similar and reached maxima at 3-6 h after smoking.
关键词：smoking;nicotine;cotinine;mutagenic activity;urine