文章基本信息

标题：化粧品用赤色201号の副色素の分析とその変異原性に関する研究
本地全文：下载
作者：宮越護 ; 早川ゆみ子 ; 永田稔等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1990
卷号：36
期号：2
页码：133-138
DOI：10.1248/jhs1956.36.133
出版社：The Pharmaceutical Society of Japan
摘要：Five subsidiary dyes of Lithol Rubine B (C.I. 15850) were synthesized to clear the chemical structures of mutagenic impurities in the commercial cosmetic Lithol Rubine B. Their analyses by HPLC were investigated and the mutagenic activities examined by Ames test by using Salmonella typhimurium TA 98 and TA 100. The subsidiary dyes and Lithol Rubine B were completely separated by the gradient HPLC analysis by using an Inertsil ODS column and acetonitrile-water-formic acid system as a mobile phase. The subsidiary dyes showed no mutagenic activities to S. typhimurium with or without S9mix. These results suggest that the mutagenic activities may not be due to the subsidiary dyes but to some reaction intermediates in the synthetic process of Lithol Rubine B.
关键词：Lithol Rubine B;commercial azo-dye;mutagenicity;Ames test;mutagenic impurity;subsidiary dye;by-product;reaction intermediate;azo-dye separation;gradient HPLC