文章基本信息

标题：サーモスプレイLC-MSによる食肉中のサルファ剤の一斉分析
本地全文：下载
作者：堀江正一 ; 斉藤貢一 ; 星野庸二等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1990
卷号：36
期号：4
页码：283-289
DOI：10.1248/jhs1956.36.283
出版社：The Pharmaceutical Society of Japan
摘要：A thermospray high-performance liquid chromatographic-mass spectrometric (LC-MS) method has been developed for the analysis of sulfonamides such as sulfachlorpyridazine, sulfadiazine, sulfadimethoxine, sulfadimidine, sulfadoxine, sulfamerazine, sulfamethoxazole, sulfamethoxypyridazine, sulfamonomethoxine, sulfaquinoxaline, sulfathiazole and sulfisomidine. The LC separation was carried out on a TSK-gel ODS-80T_M by using 0.05 M ammonium acetate (pH 4.5)- acetonitrile (7 : 3) as the mobile phase, at a flow rate of 0.8 ml/min. The vaporizer temperature was set to 155°C and ion source block temperature to 280°C. The mass spectra obtained from sulfonamides were very simple, with base peaks corresponding to protonated molecular ions MH⁺. The calibration curve for sulfadimidine was rectilinear from 0.2 to 20 ng with the detection limit by selected ion monitoring (SIM) was about 100 pg. Similar results were obtained with other sulfonamides. An excellent correlation between the results of the thermospray LC-MS method and HPLC method was obtained (γ=0.981).
关键词：sulfonamide;residual analysis;liquid chromatography-mass spectrometry;thermospray;meat