文章基本信息

标题：重金属による免疫機能の修飾
本地全文：下载
作者：大沢基保
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1990
卷号：36
期号：4
页码：255-266
DOI：10.1248/jhs1956.36.255
出版社：The Pharmaceutical Society of Japan
摘要：Immune function is susceptible to nutritional and environmental status of heavy metals. The common immunological manifestations and related health effects are described resulting from deficiencies of essential heavy metals and excess exposure to essential or toxic heavy metals. T cell dysfunction in zinc deficiency exemplifies immunosuppression in deficiencies of essential metals. It may be due to impairment of zinc-dependent metabolism in immune cells and/or decreased activity of thymulin, a zinc-dependent thymic hormone. The exposure to cadmium as well as mercury can stimulate immune cells to induce autoantibody formation, which requires the presence of T cells and seems to be associated with development of glomerulonephritis. Thus T cells may interact more selectively with zinc, cadmium and presumably other heavy metals. Immunological disturbance associated with heavy metals can be a model for studying potential risks of chronic diseases originated from nutritional and environmental status.
关键词：heavy metal;nutritional deficiency;environmental exposure;immunosuppression;zinc;thymulin;T cell function;autoimmune response;cadmium