文章基本信息

标题：Microbial Degradation of Disinfectants. II. Complete Degradation of Chlorhexidine
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作者：YUTAKA KIDO ; HIROFUMI KODAMA ; FUMINORI URAKI 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1988
卷号：34
期号：2
页码：97-101
DOI：10.1248/jhs1956.34.97
出版社：The Pharmaceutical Society of Japan
摘要：The complete microbial degradation of chlorhexidine is described. Two new isolates of bacteria (strains No. A-1 and No. A-3) utilized chlorhexidine as a sole nitrogen source for growth. The growth yield of both strains was about 60 g of protein per mol of nitrogen of chlorhexidine, and was similar to that in the case of ammonium ion as a nitrogen source. Different degradation patterns of chlorhexidine were observed on the high-performance liquid chromatograms (HPLC) of the culture filtrates of the strains. The strain No. A-3 (Pseudomonas sp.) was found to form transient intermediates, detectable on the HPLC, during the microbial degradation, whereas the strain No. A-1 (Flavobacterium sp.) degraded chlorhexidine without formation of such transient intermediates.
关键词：chlorhexidine;complete microbial degradation;sole nitrogen source;growth yield;intermediate