文章基本信息

标题：マウス臓器中のメタロチオネイン濃度に対する化合物の影響(第4報)肝臓疾患用剤による肝臓メタロチオネイン濃度の増加
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作者：小野坂敏見 ; 越智洋子 ; 閔庚善等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1989
卷号：35
期号：5
页码：328-332
DOI：10.1248/jhs1956.35.328
出版社：The Pharmaceutical Society of Japan
摘要：The concentration of metallothionein in the liver of mice injected with drugs for hepatic diseases was determined, and the following results were obtained. 1. The concentration of metallothionein in the liver was increased by the injection of glutathion, N-(2-mercaptopropionyl) glycine, protoporphyrin or Shosaikoto. 2. Among sulfur compounds, an injection of L-cysteine or L-cysteic acid increased the concentration of metallothionein in the mouse liver. 3. Metallothionein induced by N-(2-mercaptopropionyl) glycine or Shosaikoto was zincthionein. Acute cadmium toxicity was prevented by the pre-injection of these compounds. These results indicate that some drugs for hepatic diseases increase the level of metallothionein in the mouse liver.
关键词：drug for hepatic disease;N-(2-mercaptopropionyl) glycine;Shosaikoto;metallothionein;liver;mouse;acute cadmium toxicity