文章基本信息

标题：トリクロロ酢酸及びトリクロロエチレンによるマウスの脂質過酸化反応と肝障害
本地全文：下载
作者：渡辺聡 ; 加藤慈子 ; 河内佐十等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1994
卷号：40
期号：5
页码：440-447
DOI：10.1248/jhs1956.40.440
出版社：The Pharmaceutical Society of Japan
摘要：The possibility that the hepatic toxicity of trichloroethylene (TCE) relates to the increase of lipid peroxide in the liver is investigated. When 0.12 mmol/kg, 0.6 mmol/kg or 1.2 mmol/kg of trichloroacetic acid (TCA) or TCE was administered to a mouse at a single dose, the content of thiobarbituric acid reactive substances in the liver increased in a dependent manner, while the contents of flavin and GSH, and the activity of mitochondrial ATP synthesis in the liver decreased. There was a significant correlation between these parameters. These results suggest that the lipid peroxidation and the decrease of mitochondrial ATP synthesis in the liver of mice caused by TCA or TCE relate to the liver injury.
关键词：liver injury;trichloroethylene;trichloroacetic acid;lipid peroxidation;ATP synthesis;free radical