文章基本信息

标题：ペンタクロロフェノールによる脂質過酸化反応に対するリボフラビン酪酸エステルの抑制効果
本地全文：下载
作者：渡辺聡 ; 加藤慈子 ; 宮坂一善等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1994
卷号：40
期号：5
页码：433-439
DOI：10.1248/jhs1956.40.433
出版社：The Pharmaceutical Society of Japan
摘要：It is suspected that pentachlorophenol (PCP), used as an organochlorine herbicide, has toxicity related with the lipid peroxidation. The lipid peroxidation by the in vitro metabolism of PCP in a microsomal system was inhibited by riboflavin tetrabutyrate (B₂-But), a fat-soluble riboflavin, but not inhibited by water-soluble flavins. The lipid peroxidation in the liver of mice exposed to 35 μmol/kg of PCP was suppressed by the simultaneous administration of B₂-But, but scarcely suppressed by other flavins. Moreover, the changes of mitochondrial ADP/O ratio and flavin contents in the liver of mice were also suppressed by B₂-But. It was considered that the suppressive effect of B₂-But on the liver injury by PCP due to the inhibition of the lipid peroxidation and the flavin supply by B₂-But in the liver.
关键词：pentachlorophenol;lipid peroxidation;riboflavin tetrabutyrate;liver injury;mitochondrial ATP synthesis