文章基本信息

标题：臭素酸カリウムの毒性学的研究(第2報)臭素酸カリウムとベンゾ[a]ピレン併用投与時における肝障害の検討
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作者：川名清子 ; 中岡正吉 ; 堀口佳哉等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1991
卷号：37
期号：4
页码：266-275
DOI：10.1248/jhs1956.37.266
出版社：The Pharmaceutical Society of Japan
摘要：The short-term in vivo expression of precarcinogenicity of potassium bromate (KBrO₃), a food additive, was examined. KBrO₃ was orally administered singly or in combination with benzo-[a] pyrene (B [a] P) or B [a] P alone, in male of 6 week-old SPF-ddy mice. KBrO₃ was given in the drinking water for two weeks at concentration of 5000, 2500, 1000, 500 or 100 ppm. KBrO₃-B [a] P simultaneous administration groups were given in the corn oil solution of B [a] P at 100 mg/kg, once a week for two weeks. The results obtained were as follows : 1. The body weight gains were inhibited by KBrO₃ of a high concentration (5000 ppm). But, after the administration the organ weights of the liver, lung and kidney showed no difference among groups administered with KBrO₃. 2. As for tumor makers, α-fetoprotein (AFP), alkaline phosphatase (EC 3.1.3.1, ALP) and γ-glutamyl transpeptidase (EC 2.3.2.2, γ-GTP) activities in the plasma were determined. The results of this experiment demonstrated that the AFP values increased in KBrO₃ groups and KBrO₃-B [a] P simultaneous groups, 2-3 fold that of the control group given distilled water alone. AFP value and ALP activitiy increased independently of the dosage of KBrO₃. Moreover, the γ-GTP activities more significantly increased in all experimental groups than that of the control, and also showed the same results additively by simultaneous administration of KBrO₃ and B [a] P. However, the γ-GTP activities in the liver were not remarkably enhanced in all experimental groups. These results suggested that formation of oxygen radicals in the target organs such as the liver, kidney and lung was closely related to KBrO₃ precarcinogenesis.
关键词：potassium bromate;benzo [a] pyrene;precarcinogenesis;interaction;toxicity;γ-glutamyl transpeptidase