文章基本信息

标题：臭素酸カリウムの毒性学的研究(第1報)臭素酸カリウムのラットにおける吸収, 代謝, 排泄
本地全文：下载
作者：川名清子 ; 中岡正吉 ; 堀口佳哉等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1991
卷号：37
期号：4
页码：258-265
DOI：10.1248/jhs1956.37.258
出版社：The Pharmaceutical Society of Japan
摘要：The acute toxicity and metabolism of potassium bromate (KBrO₃), used as a food additive and a neutralizer in permanent wave chemicals, were examined by oral administration (85, 159, 325 and 602 mg/kg) to male and female adult Wistar rats. The results obtained were as follows : 1. There was no death in the animal treated with KBrO₃ in a dose of 85 mg/kg after 72 h of administration, but about 20% of the animals treated with KBrO₃ in a dose of 159 mg/kg survived. The LD₅₀ value of KBrO₃ in rats was estimated to be 157 mg/kg. 2. After administration, KBrO₃ was absorbed rapidly as bromate from the stomach and reduced partially in the gastric pouch, and about 95% of KBrO₃ disappeared from the stomach in 30 min. 3. The trace amount of methemoglobin was detected in the blood of animals, but the presence of hemochromatosis were observed significantly on the kidney, spleen and liver. 4. Until 24 h after administration, about 13% of KBrO₃ was excreted in the urine. Nevertheless, the residue of this bromate was not found in the kidney, spleen, liver and other organs. It was suggested that almost all KBrO₃ disappeared in the target organ cells through metabolic reduction systems.
关键词：potassium bromate;absorption;metabolism;excretion;toxicity