文章基本信息

标题：Chemical Forms of Nickel in Rat Plasma, Kidney Cytosol and Urine after Administration of 63NiCl2
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作者：KATSUHIKO NAKAMURO ; YASUYOSHI SAYATO
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1989
卷号：35
期号：1
页码：19-29
DOI：10.1248/jhs1956.35.19
出版社：The Pharmaceutical Society of Japan
摘要：The binding of ⁶³Ni to low-molecular-weight constituents of rat plasma, kidney cytosol and urine has been investigated in vivo and in vitro. Comparative tissue distribution and excretion of ⁶³Ni in rats after administration of ⁶³NiCl₂ through various routes revealed that among rat organs, the kidney showed the highest affinity for ⁶³Ni and that radio-nickel was excreted easily into the urine by way of the kidney. Sephadex G-25 and G-200 gel chromatographies of plasma, kidney cytosol and urine after iv or po administration of ⁶³NiCl₂ demonstrated that a major component of nickel metabolite in the rat urine may originate from one of three Ni-complexes with low molecular weight in the plasma and kidney cytosol. The behaviors of Ni-complex on thin layer chromatography and Sephadex G-25 gel chromatography suggested that one of the metabolites in the rat urine after iv or po administration of ⁶³NiCl₂ existed as a complex of nickel with a picrate-forming substance resembling creatine-related substances.
关键词：nickel chloride;chemical form;rat plasma;rat kidney cytosol;rat urine;picrate-forming substance;creatine;creatine phosphate