文章基本信息

标题：希土類元素の生体影響に関する研究(第4報)4種希土類元素(Dy, Eu, Yb, Y)静脈内投与時のラット臓器内Ca, Mg及びP含量の変動
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作者：中村優美子 ; 津村ゆかり ; 外海泰秀等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1993
卷号：39
期号：1
页码：44-55
DOI：10.1248/jhs1956.39.44
出版社：The Pharmaceutical Society of Japan
摘要：Effects of rare earth elements (REEs) on the time courses of REE, Ca, Mg and P concentrations in the liver, kidney, spleen, lung, femur and whole blood were investigated in the male rats of Wistar strain. Four kinds of REE salts, i.e. dysprosium chloride (DyCl₃), europium chloride (EuCl₃), ytterbium chloride (YbCl₃) and yttrium chloride (YCl₃)], were administered intravenously from the caudal vein (10 mg/kg as REE). Contents of REE, Ca, Mg and P were estimated by the wet digestion-ICP-AES method as a function of time. Results were as follows : 1) Concentrations of Ca in the liver, spleen and lung increased extremely in the rat administered with YCl₃. Pattern of hepatic Ca concentration as a function of time was similar to that of hepatic Y concentration, and Ca concentration was not significantly different from the control group at 45th d after the administration. Patterns of Ca concentrations were different from Y in the spleen and lung. REEs administration did not affect significantly the concentrations of Ca, Mg and P in the liver, kidney, spleen and lung except the concentrations of Ca in the liver, spleen and lung of Y-administered rats. 2) Concentrations of Ca, Mg and P in the whole blood of REE-administered rats varied from the control group within 1 d after the administration. 3) No significant effects were observed in the femoral Ca, Mg and P concentrations. 4) Concentrations of REEs in the whole blood and liver decreased exponentially in the ranges of 15 min-1 d and 1-45 d (8 h-45 d in case of YCl₃-administered rats) respectively. The half lives of Dy, Eu, Yb and Y were calculated as 6.94, 6.78, 6.84 and 0.427 h for the whole blood, and 16.2, 21.0, 15.5 and 19.3 d for the liver, respectively.
关键词：dysprosium chloride;europium chloride;ytterbium chloride;yttrium chloride;intravenous administration;calcium