文章基本信息

标题：トリクロロ酢酸のIn Vitro代謝に伴う脂質過酸化反応に対するフラビン誘導体の抑制効果
本地全文：下载
作者：渡辺聡 ; 山本香 ; 加藤慈子等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1994
卷号：40
期号：2
页码：171-177
DOI：10.1248/jhs1956.40.171
出版社：The Pharmaceutical Society of Japan
摘要：The possibility of hepatic toxicity of trichloroethylene (TCE) related to the increase of lipid peroxide in the liver was investigated. Trichloroacetic acid (TCA) and dichloroacetic acid (DCA) were dominant metabolites of TCE in the liver, so that TCA was metabolized in vitro by microsomes and lipid peroxidation was measured as an oxygen uptake by the oxygen electrode method. The increase of lipid peroxidation with the metabolism of TCA and the TCA-induced lipid peroxidation was inhibited by mannitol, uric acid and flavin derivatives, but scarcely inhibited by superoxide dismutase and catalase. Moreover, non-enzymic DCA radical production induced by 2, 2'-azobis (2-amidinopropane) dihydrochloride was inhibited by radical scavengers and flavin derivatives. These results suggest that the active oxygen scarcely contributes to the lipid peroxidation with the metabolism of TCA and that the inhibitory effect of flavin derivatives depends on the affinity for DCA radical and lipid peroxide radical.
关键词：trichloroacetic acid;dichloroacetic acid;lipid peroxidation;flavin derivatives;oxygen uptake