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标题：ビタミンC強化食摂餌による臭素酸カリウムの毒性軽減効果
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作者：川名清子 ; 中岡正吉 ; 堀口佳哉等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1994
卷号：40
期号：2
页码：154-161
DOI：10.1248/jhs1956.40.154
出版社：The Pharmaceutical Society of Japan
摘要：The antioxidative effects of vitamin C (VC) on the toxicity of potassium bromate (KBrO₃), a food additive, were examined. Five-week-old SPF-SD male rats were fed the VC enriched diets (310, 1310 and 3310 μg/g) for 4 weeks, and KBrO₃ was given in the drinking water for 4 weeks at concentration of 500 μg/ml, simultaneously. The results obtained were as follows : 1. The activities of alkaline phosphatase (EC 3.1.3.1, ALP) and γ-glutamyl transpeptidase (EC 2.3.2.2, γ-GTP) in the kidney cytosols were suppressed depending upon the concentration of VC in the diets, but the activities of glutamic pyruvic transaminase (EC 2.6.1.2, GPT) and glutamic oxaloacetic transaminase (EC 2.6.1.1, GOT) were not effected by the concentration of VC in the diets. 2. The thiobarbituric acid reactive substances (TBARS) contents in the kidney homogenate and serum were increased by the administration of KBrO₃, and decreased by the coadministration of VC enriched diets. However, the TBARS contents in the liver were almost constant. These results suggested that the increase of TBARS contents in the kidney and serum is correlated with the administration of KBrO₃ and that the protective effects of VC to the toxicity of KBrO₃ were unremakable. However, the TBARS contents were decreased by the simultaneous administration of VC enriched diets.
关键词：potassium bromate;vitamin C;toxicity;interaction;lipid peroxidation;kidney