文章基本信息

标题：さまざまなストレスに応答する不思議な酵素 : ヘムオキシゲナーゼ
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作者：藤田博美 ; 武田和久 ; 伊原直美等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1995
卷号：41
期号：1
页码：14-23
DOI：10.1248/jhs1956.41.14
出版社：The Pharmaceutical Society of Japan
摘要：Heme oxygenase (HO : EC 1.14.99.3) is a key enzyme for heme catabolism and catalyzes the oxidative degradation of heme to form biliverdin IXa, an immediate precursor of bilirubin. The HO activity can be induced by treatment with hemin, the substrate itself, as well as with various other non-heme stress inducers. Recently, it has been shown that HO is a major 32 kDa stress protein inducible by treatments with heavy metals, heat shock, or acute phase inducers. The induction of HO is considered to be a member of the defense system against environmental hazards, because bilirubin is one of the antioxidants. Among two isozymes of HO, i.e., HO-1 and HO-2, only HO-1 is inducible. In the present article, therefore, we described the molecular mechanisms of HO-1 gene activation by environmental hazards. We also discussed the HO-1 gene regulation during differentiation of erythrocytes and monocytes.
关键词：heme oxygenase;isozyme;gene activation;heat shock;acute phase;heavy metal