文章基本信息

标题：Urinary Excretion Levels of Osseous Collagen Metabolites in Cadmium Workers
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作者：KAZUHIRO YOSHIHARA ; KATSUAKI TAKAHASHI ; MINORU NAGATA 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1995
卷号：41
期号：4
页码：300-305
DOI：10.1248/jhs1956.41.300
出版社：The Pharmaceutical Society of Japan
摘要：The toxic effect of a trace amount of inhaled cadmium oxide (CdO) dust on bone collagen metabolism in workers who were employed in a Ni-Cd battery plant (Cd-workers) was investigated by measuring the urinary excretion levels of hydroxylysine glycosides (Hyl-Gs) and hydroxylysylpyridinoline (Pyr) as bone collagen metabolites. Urinary Cd levels in the Cd-workers were apparently higher than control levels, but urinary β₂-microglobulin levels were within control levels. There was no statistically significant difference between the urinary Hyl-Gs levels of the Cd-workers and those of age-adjusted controls who were not engaged in Ni-Cd battery making at the same plant. The urinary Pyr levels of the Cd-workers, however, were slightly higher than age-adjusted control levels, but statistical significance was not observed except for those in their forties. These results suggest that inhaled CdO dust is involved in osseous collagen metabolism in some way, especially in bone resorption.
关键词：cadmium oxide;bone metabolism;hydroxylysylpyridinoline;hydroxylysine glycoside;urinary excretion