文章基本信息

标题：Method of Determining the Inhalation Deposition of Mutagenic Components in Environmental Tobacco Smoke Aerosol
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作者：Sumio GOTO ; Kazutoshi SUGITA ; Osamu ENDO 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1997
卷号：43
期号：2
页码：123-128
DOI：10.1248/jhs1956.43.123
出版社：The Pharmaceutical Society of Japan
摘要：Total inhalation deposition of direct-acting mutagenicity associated with environmental tobacco smoke (ETS) aerosol was measured in a human volunteer. The exposures were conducted in a normal office containing well circulated ETS. The ETS aerosol was collected by filtration in the exhaled air using the Hans Rudolph mask connected to a filter holder and respirometer. The inhaled indoor air was collected by low volume air sampler. The direct-acting mutagenicity of the aerosol was determined using the ultramicrosuspension forward mutation assay in Salmonella typhimurium strain TM677. The deposition ratio was estimated as ca. 55% from the difference of the mutagenicity between exhaled and inhaled air.
关键词：ETS;direct-acting mutagen;inhalation deposition;ultramicrosuspension forward mutation assay