文章基本信息

标题：各種クロラミンによるポリオウイルスの不活化
本地全文：下载
作者：立川眞理子 ; 松野綾子 ; 手塚雅勝等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1997
卷号：43
期号：4
页码：230-236
DOI：10.1248/jhs1956.43.230
出版社：The Pharmaceutical Society of Japan
摘要：Inactivation rates for poliovirus (Lsc, 2ab strain), suspended in a phosphate buffer salt solution (PBS) and a cell maintenance medium (MEM), with chloramines, N-chlorosuccinimide (Cl-SI), chloramine T (Cl-T), ammoniamonochloramine (NH₂Cl), N-chlorodiethylamine (ClDEA) and N-chloroglycine (Cl-Gly) at 2 and 10 mg/l as available chlorine (Cl₂), were determined at pH 7 and 20°C. Inactivation efficacies of these chloramines were compared each other and discussed in relation to chemical potency, hydrolysis constants and chlorination rates for the chloramines. At 10 mg/1 as Cl₂, the periods for the 99% inactivation of the virus suspended in PBS with Cl-SI, Cl-T, and NH₂Cl were 2.5, 5, and 5 min, respectively. However, Cl-DEA and Cl-Gly did not reach 99% inactivation in 10 min contact. There were a little chlorine consumption in the test solutions of Cl-SI, Cl-T, and NH₂Cl but of Cl-DEA and Cl-Gly. The inactivation efficacies of these chloramines did not correspond to the order of their hydrolysis constants. The faster chlorination rate for Cl-SI than tested other chloramines may have an influence on its faster inactivation rate. Inactivation rates for the virus suspended in MEM with the chloramines were slower than that for the virus suspended in PBS. It might be due to the formation of less effective chloramines from constituents in MEM virus suspension.
关键词：chloramine;poliovirus inactivation rate;hydrolysis constant;chlorination rate;virus suspension