文章基本信息

标题：Oxidation of 1-Methyl-3-ethylpyridinium Salt (A Correction)
本地全文：下载
作者：Shigehiko Sugasawa ; Makoto Kirisawa
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1956
卷号：4
期号：2
页码：139-140
DOI：10.1248/cpb1953.4.139
出版社：The Pharmaceutical Society of Japan
摘要：The report made by Sugasawa and Ban that the oily oxidation product, produced in 66% yield, of 1-methyl-3-ethylpyridinium methosulfate consisted of 1-methyl-3-ethyl-2-pyridone only, was in error, which was caused by a cursory examination of the distillation product. The present study revealed that the oily oxidation product was really a mixture of 1-methyl-3-ethyl-2-and-6-pyridone in proportion of approximately 8 : 1. Their separation was made possible through picrates, of which the one from the 2-pyridone is freely soluble in ether, whereas the other is practically insoluble in cold ether. By using the oxidation agent in a certain excess, the yield of the product attained as high as 84% of the theoretical.