文章基本信息

标题：Studies on Anthemintics. XXXII. The Absolute Configuration of Santonin Isomers. (2). Synthetic Santonins
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作者：Masao Sumi
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1956
卷号：4
期号：3
页码：162-167
DOI：10.1248/cpb1953.4.162
出版社：The Pharmaceutical Society of Japan
摘要：New optically active stereoisomers of santonin were synthesized and their absolute configurations investigated. It has been shown that(-)-6α-hydroxy-3-oxo-11-epi-isoeusatona-1, 4-dienic acid lactone, (-)-6β-hydroxy-3-oxoeusantona-1, 4-dienic acid lactone, and (-)-6β-hydroxy-3-oxo-11-epi-eusantona-1, 4-dienic acid lactone are of the same stereochemical type as that of the naturally occurring santonins. An aspect of the mechanism of the dienone-phenol rearrangement in santonin series was also considered.