文章基本信息

标题：局所麻酔剤の微量分析法(III) : 脳脊髄液中の局所麻酔剤の分析法について
本地全文：下载
作者：武田寧 ; 丹沢珪子 ; 星野乙松等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1966
卷号：12
期号：3
页码：138-143
DOI：10.1248/jhs1956.12.138
出版社：The Pharmaceutical Society of Japan
摘要：The conversion of local anesthetics in human cerebro-spinal fluid was investigated in vitro and an improved method for analysis of the local anesthetics in cerebro-spinal fluid was proposed. When hexylcaine, procaine and tetracaine were incubated with cerebro-spinal fluid, ester bonds of the compounds were hydrolysed mainly due to the increase of pH of cerebro-spinal fluid on standing, while amide bonds of dibucaine, lidocaine and carbocaine were unchanged. In the analysis of local anesthetics in cerebro-spinal fluid, it is desirable to estimate the ultra-violet spectrum of the sample and to determine the aromatic carboxylic acid liberated, as well as the determination of the unchanged anesthetics.