文章基本信息

标题：Hepatic Glycogen Metabolism in Mice injected with Vibrio parahaemolyticus Endotoxin
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作者：OSAMU SAKAGUCHI ; JUNKO TAKEDA ; SHUHEI SAKAGUCHI 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1976
卷号：22
期号：2
页码：61-64
DOI：10.1248/jhs1956.22.61
出版社：The Pharmaceutical Society of Japan
摘要：Changes of some metabolite and enzyme activities concerned with hepatic glycogen metabolism in mice were investigated by the intraperitoneal injection of endotoxin extracted from Vibrio parahaemolyticus. A marked depletion of hepatic glycogen, a considerable increase in blood sugar and a remarkable increase in blood-lactic acid amount were observed in the poisond mice 1-3 hr postintoxication. There was an increase in the activities of hepatic phosphorylase and G-6-Pase at 1 hr postintoxication, but the latter activity decreased thereafter. Hyperglycemia of mice was found in proportion to the dose of endotoxin, but mice injected with a large quantity (40 mg/kg) of endotoxin showed evident hypoglycemia after 16 hr.