文章基本信息

标题：Metabolic Products of Fungi. V. The Structure of Skyrin. (1)
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作者：Shoji Shibata ; Osamu Tanaka ; Isao Kitagawa 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1955
卷号：3
期号：4
页码：278-283
DOI：10.1248/cpb1953.3.278
出版社：The Pharmaceutical Society of Japan
摘要：The structure of skyrin and its reductive cleavage with Na₂S₂O₄ giving emodin were discussed using some model compounds, 4, 4'-dihydroxy-, 2, 2'-dihydroxy-, and 2, 2'-dimethoxy-4, 4'-dihydroxy-bianthraquinones-(1, 1'). The latter two compounds were subjected to the cleavage reaction with Na₂S₂O₄. Dimethyl ether of skyrin prepared by the action of methanol and conc. H₂SO₄ was proved to be different from dimethyl ether prepared with diazomethane, the latter yielded physcion by reductive cleavage. It was considered that the latter is a genuine dimethyl ether of skyrin while an isomerized form was suggested for the former compound designating pseudoskyrin dimethyl ether. A formula, 2, 4, 5, 2', 4', 5'-hexahydroxy-7, 7'-dimethylbianthraquinone-(1, 1') was proposed for skyrin.