文章基本信息

标题：Chemicopharmacological Studies on Antispasmodic Action. VI. On Statistical Treatment of Concentration-Action Relationship of Acetylcholine on Small Intestines of Mice.
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作者：Keijiro Takagi ; Masayasu Kimura
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1956
卷号：4
期号：6
页码：449-453
DOI：10.1248/cpb1953.4.449
出版社：The Pharmaceutical Society of Japan
摘要：1) A concentration-action relationship of acetylcholine was demonstrated using isolated intestines of 20 mice. 2) For mean responses of six acetylcholine concentrations was fitted a logistic sigmoid curve by the method of maximum likelihood. 3) The maximum likelihood estimate of the mean slope was 1.146, which was proved not to be significantly different from the theoretical value of one.